These are in order from least shocking to most shocking according to the current lines at the ESPN Bet Sportsbook.
| Oregon (+3.0) vs. Ohio State- 7:30 |
| Northern Illinois (+3.0) at Bowling Green- 3:30 |
| Denver (+3.0) vs. LA Chargers- (Sun) 4:05 |
| West Virginia (+3.0) vs. Iowa State- 8:00 |
| Dallas (+3.5) vs. Detroit- (Sun) 4:25 |
| Middle Tennessee (+5.0) at Louisiana Tech- (Th) 8:00 |
| Southern Cal (+5.5) vs. Penn State- 3:30 |
| UCLA (+5.5) vs. Minnesota- 9:00 |
| North Carolina (+6.0) vs. Georgia Tech- 12:00 |
| Rice (+6.5) vs. UTSA- 7:00 |
| Florida Atlantic (+6.5) vs. North Texas- 7:00 |
| Buffalo (+9.5) vs. Toledo- 12:00 |
| Vanderbilt (+14.0) at Kentucky- 7:45 |
| Arkansas State (+14.5) at Texas State- 7:00 |
| Oklahoma (+14.5) vs. Texas- 3:30 |
Last week’s Upset Pick of the Week: Syracuse (+6.5) over UNLV
