These are in order from least shocking to most shocking according to the current lines at the Bet ESPN Sportsbook.
| Syracuse (+3.5) vs. Boston College- 3:00 |
| Utah State (+3.5) vs. (Fri) Boise State |
| Auburn (+6.5) vs. Alabama- 7:30 |
| Buffalo (+6.5) vs. Ohio- (Fri) 12:00 |
| Washington (+6.5) vs. Oregon- 3:30 |
| Virginia Tech (+9.5) vs. Virginia- 7:00 |
| Carolina (+10.5) vs. LA Rams- (Sun) 1:00 |
| Sam Houston (+10.5) vs. FIU- 1:00 |
| LSU (+10.5) at Oklahoma- 3:30 |
| UL-Monroe (+10.5) at UL-Lafayette- 3:00 |
| Kansas (+13.5) vs. Utah- (Fri) 12:00 |
| Rutgers (+13.5) vs. Penn State- 3:30 |
| California (+13.5) vs. SMU- 8:00 |
Last week’s Upset Pick of the Week: Wisconsin (+7.5) over Illinois
