These are in order from least shocking to most shocking according to the current lines at the DraftKings Sportsbook.
| Pittsburgh (+3.0) at Virginia Tech- (Fri) 7:00 |
| West Virginia (+3.5) at Iowa State- 12:00 |
| Commanders (+3.5) vs. Colts- (Sun) 9:30 AM |
| NC State (+3.5) vs. Louisville- 3:30 |
| Missouri (+5.5) vs. Florida- 3:30 |
| Eastern Michigan (+6.5) at UMass- 3:30 |
| UConn (+6.5) vs. Syracuse- 12:00 |
| TCU (+6.5) vs. BYU- 7:00 |
| Delaware (+7.0) at Liberty- (Fri) 7:00 |
| Michigan State (+10.0) at Wisconsin- 12:30 |
| Stanford (+12.5) at Wake Forest- 12:00 |
| Iowa (+14.0) vs. Ohio State- 3:30 |
| Clemson (+16.5) vs. Miami-FL- 7:30 |
Last week’s Upset Pick of the Week: UCF (+3.0) over TCU
